1-(methylthio) amino methyl ethyl carbamate
Methomyl
CAS: 16752-77-5
Molecular Formula: C5H10N2O2S
1-(methylthio) amino methyl ethyl carbamate - Names and Identifiers
1-(methylthio) amino methyl ethyl carbamate - Physico-chemical Properties
| Molecular Formula | C5H10N2O2S |
| Molar Mass | 162.21 |
| Density | d424 1.2946 |
| Melting Point | 78°C |
| Boling Point | 144°C |
| Water Solubility | Soluble. 5.8 g/100 mL |
| Vapor Presure | 0Pa at 20℃ |
| Appearance | solid |
| Exposure Limit | NIOSH REL: TWA 2.5 mg/m3; ACGIH TLV: TWA 2.5 mg/m3. |
| Merck | 13,6012 |
| BRN | 3081564 |
| pKa | 13.27±0.46(Predicted) |
| Storage Condition | 0-6°C |
| Stability | Stable. Incompatible with strong bases, strong oxidizing agents. |
| Refractive Index | 1.6430 (estimate) |
| Physical and Chemical Properties | Melting point 78°C boiling point 144°C water-Soluble Soluble. 5.8g/100 mL |
| Use | Is a broad-spectrum, rapid-acting insecticide, effective against aphids, cotton bollworm and other pests, can be used for food, cotton, vegetables, tobacco, fruit and other crops |
1-(methylthio) amino methyl ethyl carbamate - Risk and Safety
| Risk Codes | R28 - Very Toxic if swallowed R50/53 - Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment. R36 - Irritating to the eyes R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R11 - Highly Flammable R36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S1/2 - Keep locked up and out of the reach of children. S22 - Do not breathe dust. S36/37 - Wear suitable protective clothing and gloves. S60 - This material and its container must be disposed of as hazardous waste. S61 - Avoid release to the environment. Refer to special instructions / safety data sheets. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S16 - Keep away from sources of ignition. S36 - Wear suitable protective clothing. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S28 - After contact with skin, wash immediately with plenty of soap-suds. |
| UN IDs | UN 2757 |
| WGK Germany | 3 |
| RTECS | AK2975000 |
| HS Code | 29309090 |
| Hazard Class | 6.1(a) |
| Packing Group | II |
| Toxicity | LD50 orally in male rats: 17 mg/kg (Kaplan, Sherman) |
1-(methylthio) amino methyl ethyl carbamate - Upstream Downstream Industry
| Raw Materials | Methylthio acetaldoxime Coke(coal) Thiourea Dimethyl sulfate Chlorine Chlorine Methylamine Acetaldehyde acetaldehyde oxime |
1-(methylthio) amino methyl ethyl carbamate - Nature
Open Data Verified Data
The product is a mixture of cis and trans isomers, mainly in CIS. White crystals. Solubility% (mass) at 25 ° C; Water 5.8, methanol 100, ethanol 142, isopropanol 22, acetone 73. In alkaline medium or at high temperatures or by sunlight are susceptible to decomposition.
Last Update：2024-01-02 23:10:35
1-(methylthio) amino methyl ethyl carbamate - Preparation Method
Open Data Verified Data
acetaldehyde is reacted with hydroxylamine sulfate in an alkaline solution to prepare acetaldoxime, which is dissolved in N-methylpyrrolidone to obtain chloroacetaldoxime by chlorination. Methanethiol and water were added to the chloro-acetaldoxime-producing solution, and a 50% sodium hydroxide solution was added dropwise at 5 ° C. Until the pH value was 6 to 7 to prepare a methomyl pyrrolidone solution of methomyl oxime. The reaction was carried out by adding triethylamine and methyl isocyanate to give oximarb.
Last Update：2022-01-01 10:11:28
1-(methylthio) amino methyl ethyl carbamate - Introduction
This standard substance is mainly used for measuring instrument calibration, analytical method evaluation and quality control, as well as the content determination and residue detection of corresponding components in related fields such as food, hygiene, environment and agriculture. It can also be used for value traceability or as a standard liquid reserve solution. It is diluted step by step and configured into various standard solutions for work. 1. Sample Preparation This standard substance is made of methomyl pure product with accurate purity and fixed value as raw material, chromatographic acetone as solvent, and accurately configured by weight-volume method. Methomyl, English name: methomyl,CAS No.: 16752-77-5 2. Traceability and Setting Method This standard substance takes the configuration value as the standard value, and uses high performance liquid chromatography-diode array detector (HPLC-DAD) to compare this batch of standard substances with quality control control samples to verify the preparation value. By using preparation methods, measurement methods and measuring instruments that meet the requirements of metrological characteristics, the traceability of the value of the standard substance is guaranteed. 3. characteristic value and uncertainty (see certificate) number name standard value (ug/mL) relative expansion uncertainty (%)(k = 2)BW10142 The uncertainty of methomyl 1004 standard value in acetone is mainly composed of raw material purity, weighing, constant volume and uniformity, stability and other uncertainty components. 4. uniformity test and stability inspection According to the JJF1343-2012 [General Principles and Statistical Principles of Standard Substance Setting], random sampling of sub-packed samples is carried out, uniformity test of solution concentration is carried out, and stability inspection is carried out. The results show that the standard material has good uniformity and stability. The standard substance is valid for 30 months from the date of setting the value. The development unit will continue to monitor the stability of the standard substance. If the value changes are found during the validity period, the user will be notified in time. 5. packaging, transportation and storage, use and precautions 1. Packaging: This standard substance is packed in borosilicate glass ampoules, about 1.2 mL/branch. When removing or diluting, the pipette quantity shall prevail. 2. Transportation and storage: ice bags should be transported, and extrusion and collision should be avoided during transportation; storage under refrigeration (2-8 ℃) and dark conditions. 3. Use: Balance at room temperature (20±3 ℃) before unsealing, and shake well. Once the ampoule is opened, it should be used immediately and cannot be used as a standard substance after being fused again.
Last Update：2022-10-16 17:14:19
1-(methylthio) amino methyl ethyl carbamate - Use
Open Data Verified Data
broad-spectrum insecticide. It has the function of internal absorption, contact and stomach poison. Suitable for cotton, tobacco, fruit trees, vegetables to control aphids, moths, land tiger and other pests, is the current control of resistant cotton aphid good alternative varieties. It is also used as an intermediate of thiobarb.
Last Update：2022-01-01 10:11:29
1-(methylthio) amino methyl ethyl carbamate - Safety
Open Data Verified Data
oral LD50 of male rats: 17 mg/ kg.
Last Update：2022-01-01 10:11:29
1-(methylthio) amino methyl ethyl carbamate - Reference Information
| LogP | 0.11 at 25.2℃ |
| NIST chemical information | Information provided by: webbook.nist.gov (external link) |
| EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
| toxicity | acute oral LD50 of rats is 17 mg/kg (male) and 24 mg/kg (female). Acute percutaneous LD50 of the original drug to rabbits> 5000mg/kg. Acute inhalation of LC50 in rats was 0.3mg/L (4h). After 2 weeks, rats were fed 10 times at a dose of 5.1 mg/kg per day without adverse effects. No irritation to the skin, moderate irritation to the eyes. No teratogenic, mutagenic or carcinogenic effects were found in the experiment. The LC50 of rainbow trout, blue gill fish and goldfish were 3.4mg/L, 0.87mg/L and 0.1mg/L(96h) respectively. The acute oral LD50 of wild ducks is 16mg/kg. Toxic to bees. |
| use | systemic carbamate insecticides, which have both contact killing and stomach toxicity, can effectively control a variety of pests and their larvae and eggs, with a short residual period. Control of cotton bollworm, cotton moth, smoke moth with 24% water 24~36mL/100m2 water spray. Foliar spray can also be used to control aphids, thrips, red spiders, leaf roller insects, armyworms, etc., and soil treatment can be used to control nematodes and leaf pests. This product is a broad-spectrum insecticide of carbamate with systemic contact and stomach toxicity. In 1966, it was first recommended by Du Pont Company of the United States as insecticide and nematicide. It is suitable for controlling aphids, moths, cutworms and other pests in cotton, tobacco, fruit trees and vegetables. It is a good replacement variety for controlling drug-resistant cotton aphids. This product is also used as an intermediate for Thiodicarb. is a broad-spectrum, quick-acting insecticide, which is effective against aphids, cotton bollworms and other pests. It can be used in crops such as grain, cotton, vegetables, tobacco, and fruits. |
| Production method | Reaction of acetaldehyde and hydroxylamine sulfate in an alkaline solution to make acetaldoxime, dissolve it in N-methylpyrrolidone, and pass in equimolar chlorine at -5 ℃ to chlorinate to produce chloroacetaldoxime. In the chloroacetaldoxime generating solution, add methyl mercaptan and water, and add 50% sodium hydroxide solution dropwise at 5 ℃ to the pH value of 6-7 to prepare methomyl oxime methyl pyrrolidone solution. Add triethylamine and methyl isocyanate to react to obtain ethoxime. Acetaldehyde is added to hydroxylamine (or hydroxylamine sulfate), and then loses a molecule of water to form acetaldoxime. Because hydroxylamine sulfate is more stable than hydroxylamine, it is not easy to be oxidized by air and is easy to store. Hydroxylamine sulfate replaces hydroxylamine and reacts in alkaline aqueous solution. The resulting acetaldoxime is chlorinated to form chloroacetaldoxime, and the reaction is carried out in a solvent (N-methylpyridone) at a temperature of -5°C. Chloroethaldoxime reacts with methyl mercaptan to form methyl thialdoxime, the reaction temperature is 5 ℃, the sodium hydroxide solution is added dropwise to the end pH value of 6~7. The above-mentioned methyledoxime is reacted with methyl isocyanate under the catalysis of tertiary amine to produce methomyl. |
| category | pesticide |
| toxicity classification | highly toxic |
| acute toxicity | oral-rat LD50: 17 mg/kg; Oral-mouse LDL0: 10 mg/kg |
| flammability hazard characteristics | thermal decomposition of toxic sulfur oxide, nitrogen oxide gas |
| storage and transportation characteristics | warehouse ventilation and low temperature drying; separate from food raw materials storage and transportation |
| fire extinguishing agent | sand, dry powder, foam |
| occupational standard | TWA 2.5 mg/m3 |
| toxic substance data | information provided by: pubchem.ncbi.nlm.nih.gov (external link) |
Last Update：2024-04-09 21:04:16
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Multiple SpecificationsSpot supply
Product Name: Methomyl in acetone Visit Supplier Webpage Request for quotationCAS: 16752-77-5
Tel: 18301782025
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Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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Raw Materials for 1-(methylthio) amino methyl ethyl carbamate